Benefits and Uses of Diazepam

Potassium Bromide for Veterinary Use

Trilostane

What Is Veterinary Compounding?

The Role of Tramadol in Veterinary Medicine

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The average garden-variety caterpillar has 248 muscles in its head.

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Posts Tagged ‘veterinary compounding’

Benefits and Uses of Diazepam

Saturday, September 12th, 2009

A benzodiazepine tranquilizer, diazepam is used in veterinary medicine to sedate, reduce anxiety, promote behavioral changes or induce muscle relaxation. Diazepam is also an anticonvulsant and can be administered to some species to stimulate appetite.

Diazepam and Veterinary Compounding

In veterinary medicine, diazepam is commonly prescribed for dogs, cats, reptiles, sheep, cattle, horses, goats and swine. Depending on the needs of the individual patient, veterinary compounding can alter the form of the drug for oral, intravenous, rectal or intramuscular administration.

Veterinary Medicine — Diazepam Uses for Dogs and Cats

Diazepam is commonly administered as a sedative, muscle relaxant, anticonvulsant or anti-anxiety medication for dogs and cats. It may be given alone or combined in veterinary compounding in order to pointedly address individual dosage needs.

Diazepam is also used in the treatment of behavioral problems, such as aggression, excessive grooming, territorial spraying and terror caused by loud noises. When treating dogs for aggression, it is possible that diazepam can produce a reverse outcome, causing amplification rather than suppression of aggressive behaviors.

As an anticonvulsant, diazepam may be used in veterinary medicine for the treatment of seizures, whether due to toxic shock or status epilepticus. However, since dogs develop a tolerance rather quickly, diazepam is not typically selected for the continued management of seizures.

Veterinary Medicine — Diazepam and Horses

While not an analgesic, diazepam is commonly administered to sedate horses prior to surgical procedures. In adult horses, diazepam is often paired with another medication in to produce the necessary level of sedation.

Diazepam can also be administered to horses as an anticonvulsant, whether alone or as part of an amalgamation of other medications. It can also assist with breeding behaviors, particularly for withdrawn stallions.

Diazepam and Potential Side Effects

Common side effects may include impaired coordination and lethargy. Aggression, excitement or marked behavioral changes are unusual side effects. In addition, while a rarity, hepatic toxicity has also been reported in some cats.

Be sure to thoroughly discuss drug interactions and additional precautions with a specialist in veterinary medicine before using diazepam for treatment.

Potassium Bromide for Veterinary Use

Saturday, September 12th, 2009

Potassium bromide is a water-soluble ionic salt compound. Potassium bromide, or KBr, is usually produced via a reaction of a bromide of iron with potassium carbonate. The brand name for KBr is Dibro-Be mono.

In 1857, Sir Charles Locock discovered the anticonvulsant and sedative traits of potassium bromide and began treating his patients. From that point, potassium bromide became a choice treatment for humans with epileptic seizures and nervous disorders until the 1912 discovery of Phenobarbital.

The introduction of Phenobarbital considerably decreased the popularity of potassium bromide in treating humans with epileptic seizures. As a result, potassium bromide is not approved by the U.S. Food and Drug Administration.

Potassium Bromide and Veterinary Medicine

Potassium bromide is often prescribed in veterinary medicine for the effective treatment of epileptic seizures in dogs. Depending on the needs of the individual patient, potassium bromide may be the sole form of treatment or used in correlation with Phenobarbital.

Potassium bromide therapy is a rarity among the feline species, as treatment may substantially increase the risk of lung inflammation. Alternative therapies are often explored for cats, such as Diazepam or Phenobarbital, before introducing potassium bromide.

In veterinary medicine, potassium bromide typically comes in a liquid of capsule form. Since it can take three to four months to reach a steady bromide blood level, patients often receive a high dosage at the onset of treatment.

Veterinary Medicine — Potassium Bromide and Potential Side Effects

Many experts in veterinary medicine consider potassium bromide to be equally, if not more effective than Phenobarbital in treating dogs for seizures. However, as with virtually all medications, the possibility of side effects does exist.

Among other potential side effects, patients taking potassium bromide may experience appetite loss, nausea, frequent urination, thirst and drowsiness, especially when treatment is initiated with a high dosage. Coughing is another possible side effect. In such cases, potassium bromide treatment may be halted.

Potassium bromide should be administered with food. Be sure to consult with a licensed specialist in veterinary medicine to arrive at the best possible treatment.

Trilostane

Saturday, September 12th, 2009

Trilostane is an enzyme inhibiting medication. Its principal use is in the treatment of canine Cushing’s disease. In some cases, trilostane may also be an appropriate treatment for horses, cats and other conditions.

Veterinary Medicine — Dogs and Cushing’s Disease

Cushing’s disease is most common in smaller dogs. Signs of Cushing’s syndrome may include increased appetite, thirst and urination, hair loss, bald patches and an enlarged abdomen. Without treatment, dogs can develop weak and calcified skin patches, hepatopathy and frail abdominal muscles.

Canine Cushing’s disease is caused by excess secretion of the adrenocorticotropic hormone, which elevates cortisol levels. Most dogs that develop Cushing’s disease have pituitary dependant hyperadrenocorticism (PDH). Those who do not have Cushing’s because of PDH have an adrenocortical tumor, which may be benign or malignant. Whether the result of an adrenal or pituitary tumor, Cushing’s disease interferes with biological mechanisms that normally function to regulate cortisol blood levels.

As of 2008, Trilostane is an FDA approved treatment for dogs with Cushing’s disease. Administering Trilostane can inhibit with the production of cortisol in the adrenal glands, adjusting the adreno-cortico hormone levels and preventing disease symptoms.

Trilostane can be administered in once-daily doses, or in smaller, more frequent doses to reduce the occurrence of side effects. It may take approximately four weeks for the drug to take effect and to notice a reduction of symptoms.

Trilostane — Other Uses in Veterinary Medicine

In addition to treatment for pituitary dependant hyperadrenocorticism, adrenocortical tumors and Cushing’s disease, Trilostane may be used to treat dogs with Alopecia X. Advancements in veterinary medicine have also led to substantial groundwork in the use of trilostane for treating horses with Cushing’s.

Additionally, while PDH in felines is rare, trilostane may be a chosen form of therapy. However, trilostane has revealed to be a less successful form of treatment for cats.

Trilostane — Drug Interactions and Potential Side Effects

Potential side effects include vomiting, reduced appetite, weight loss, diarrhea and tiredness. Rare instances of death have been reported. As each patient reacts differently to trilostane, arriving at the appropriate dosage is crucial in preventing instances of overdose and achieving the best possible outcome.

What Is Veterinary Compounding?

Saturday, September 12th, 2009

Veterinary compounding refers to the modification of a drug in order to address the unique needs of a patient. For example, a pet pharmacist or veterinarian may take steps to improve the flavor of a medication, combine medications to achieve the best possible dosage or alter the form of a drug to be more easily administered.

Benefits of Veterinary Compounding

Drug compounding is especially useful in veterinary medicine, as numerous medications are no longer offered directly through the manufacturer or are otherwise unavailable in the required drug mixture or dosage. With veterinary compounding, the specific medication requirements of each patient can be met accurately and successfully.

Formulating the proper strength or combination of a drug is only half of the battle. In veterinary medicine, patients often balk at distasteful medications, proving wholly uncooperative when the time comes to administer treatment. Veterinary compounding eases the treatment process by modifying the pharmaceutical potency or combination and improving the palatability of the medication in question.

Regulations for Veterinary Compounding

Drug compounding is an integral part of veterinary medicine and must comply with federal and state regulations. Among other mandates, veterinary compounding must be carried out by a certified veterinarian or licensed pet pharmacist under the order of a qualified practitioner of veterinary medicine. Additionally, the compounded medication must be a safe and appropriate course of treatment. The dosage must also correspond with the specific needs of the patient.

Diamondback Drugs offers a variety of treatment solutions and carries a widespread selection of medications, along with a comprehensive range of bases and flavors. Our expert staff of pharmacists and technicians has successfully completed extensive training in veterinary compounding and are fully equipped to fulfill the varying needs of prescribers and patients.

The Role of Tramadol in Veterinary Medicine

Saturday, September 12th, 2009

Under the brand name Ultram, Tramadol is an analgesic that can help control moderate to severe pain. While Tramadol binds to opiod receptors, it is not considered an opiate. As a result, Tramadol does not produce the sedative or addictive properties frequently associated with opiates.

Tramadol may be administered in veterinary medicine to provide pain relief for animals suffering from chronic conditions such as cancer or arthritis. It can also be used for pain management following injury or surgery.

Veterinary Medicine — Tramadol and Canine Arthritis

In veterinary medicine, non-steroidal anti-inflammatory drugs are often used for pain management associated with canine arthritis. NSAIDs inhibit the production of the enzyme cyclo-oxygenase, which in turn reduces pain and inflammation. However, as cyclo-oxygenase also helps produce essential biochemicals, suppression of this enzyme can prove problematic in some patients.

Tramadol can provide the requisite pain relief for dogs suffering from chronic arthritis without the risk of developing kidney or liver problems associated with non-steroidal anti-inflammatory medications. In veterinary medicine, Tramadol may be used exclusively or in tandem with non-steroidal anti-inflammatory drugs.

Veterinary Medicine — Tramadol and Felines

Since non-steroidal anti-inflammatory drugs are dangerous for the feline species, Tramadol may provide a safer alternative and can be administered to cats in the treatment of pain.

Tramadol — Side Effects and Drug Interactions

In veterinary medicine, Tramadol is compatible with all cyclo-oxygenase interfering NSAIDs, as well as MSM, glucosamine and some other joint pain nutriceuticals. However, Tramadol should not be administered to animals taking L-Deprenyl, monoamine oxidase inhibitors, tricyclic antidepressants and serotonin reuptake inhibitors.

Common side effects of Tramadol may include upset stomach, constipation, pupil constriction, decreased heart rate and coughing. Seizures, notable mental changes and pinpoint pupils may indicate overdose. In addition, since Tramadol is processed through the liver and kidneys, an adjustment of the dosage may be necessary for patients with associated problems.