Voriconazole Antifungal Medication Can Be Very Effective
Voriconazole is an antifungal medication that is a derivative of the drug fluconazole. The main difference between the two is that voriconazole is shown to be more effective against a wider number of fungal organisms.
How Is Voriconazole Used in Veterinary Medicine?
Voriconazole is often used by veterinarians to treat pets that are infected by fungal organisms that have developed a resistance to fluconazole and other antifungal drugs like itraconazole and amphotericin-B. Due to the broadness of its fungicidal activity, voriconazole is most commonly used to treat aspergillus infections as well as candida, fusarium, and Cryptococcus.
Voriconazole Side Effects
Voriconazole is usually a safe drug when administered in appropriate dosages, with the most common side effects including nausea and vomiting. But, some pets have displayed side effects that involve the liver, the kidneys, and the adrenal glands.
In toxicology studies, voriconazole was shown to play a role in the development of hepatotoxicosis in dogs when being treated with the drug for acute or chronic fungal infections. Cell necrosis was also reported in studies, as were an increase in alanine transaminase and alkaline phosphatase activities.
Other adverse effects included centrilobular hypertrophy, increase in liver weight, and the proliferation of smooth endoplasmic reticulum. In cats, voriconazole can also cause ataxia, decreased menace response, arrhythmia, and hypokalemia.
In studies conducted on rats, the rats that were treated with high intravenous doses of voriconazole displayed signs of depression, loss of balance, dyspnea, pupil dilation, prostration, drooping eyelids, and extensor rigidity.
If the patient does display serious side effects, then she will need to undergo withdrawal from the drug, after which the side effects should subside.
Voriconazole Drug Interactions
It is recommended that Voriconazole not be used on pregnant patients or those that have known allergic reactions to it or to fluconazole. Voriconazole can also have unwanted interactions with a variety of other drugs, including amphotericin B, oral anti-diabetic agents, warfarin, quinidine, rifampin, phenytoin, certain benzodiazepines, and cyclosporine.
Phenobarbital is another drug that can interact with voriconazole. When these two are taken together, the phenobarbital has been shown to elevate the metabolism of voriconazole, causing it to be less effective.
Diamondback Drugs can custom-compound voriconazole in several different formulations, including oral, injectable, and powder forms. Thus, we can create the ideal formulation to meet any veterinarian prescription for the drug. We can even provide you a free quote for your voriconazole prescription, so you know the cost before you order.
If your pet is positively diagnosed with a fungal infection and your vet prescribes voriconazole to treat it, try Diamondback Drugs today. Our veterinary compounding pharmacy can help you get your pet the fungicidal medicine she needs to recover from a fungal infection.
Author: Giano Panzarella