Cisapride is a gastrointestinal prokinetic that is commonly used for the treatment of conditions that compromise stomach motility, prevent the movement of food and create delayed gastric emptying. A motility agent for the stomach, Cisapride normalizes stomach contractions and increases the movement of the gastrointestinal tract.

Cisapride for Veterinary Medicine — Uses in Cats and Dogs

Cisapride is often used to treat cats and dogs for a variety of motility disorders that lead to delayed gastric emptying. Cisapride is commonly prescribed in veterinary medicine for the treatment and management of Megacolon and chronic constipation in cats, as well as Megaesophagus in dogs.

Veterinary Medicine — Cisapride and Horses

Post-operative ileus (POI), a complication that leads to intestinal obstruction and bowel blockage, can occur in horses following abdominal surgery. However, some horses do not respond well to Cisapride treatment for POI, whether due to species differences or other factors. In addition, there are several causes for POI, such as inflammation and distension, which may influence the response of the patient to Cisapride treatment.

Cisapride — Complications and Precautions in Veterinary Medicine

The most common side effects of Cisapride treatment are related to the digestive tract. When the motility effects are too great, patients can experience diarrhea, abdominal pain and cramping.

Speak to your veterinarian about other possible side effects and precautions before administering Cisapride. In veterinary medicine, some conditions do not respond well to prokinetic drug therapy. Animals with compromised liver function will likely require a lower dose to prevent complications and pregnant or lactating animals are typically not given Cisapride. Animals with cardiac irregularities may also require periodic monitoring from a specialist in veterinary medicine.

Cisapride is not typically administered with a number of other drug treatments, including IV miconazole, clarithromycin. fluconazole, ketoconazole, troleandomycin, itraconazole and erythromycin. Cisapride may also increase the effect of anticoagulants and impinge on the absorption of other medications.

Cisapride Indications for Veterinary Use

In veterinary medicine, drug administration is typically recommended 15 minutes before eating. Cisapride is usually taken orally, but is also available as a transdermal gel and liquid solution or suspension.