Protecting Your Pets During Chemotherapy Treatment

Dexrazoxane is a chelating agent and a derivative of EDTA (Ethylenediaminetetraacetic acid). It is used in veterinary medicine to protect against damage caused by some types of chemotherapy. This medication is only administered through intravenous injection or infusion by a veterinarian on an inpatient basis.

Pharmacology of Dexrazoxane

The exact mechanism by which Dexrazoxane works is not entirely known, but research suggests that the medication is converted on an intracellular level into a ring-opened chelating agent that effectively interferes with the generation of iron-mediated free radicals.

Dexrazoxane Precautions and Potential Interactions

Dexrazoxane should be used with caution in cases in which the animal patient is suffering from bone marrow suppression, heart disease or kidney disease. If the patient has an allergy to this drug or other foods, dyes or preservatives, then the animal should not receive Dexrazoxane. It should also be avoided in pregnant or lactating animals.

While Dexrazoxane is not known to interact negatively with any other medications, it is still important to notify the treating veterinarian of the patient’s drug regimen prior to treatment.

Dexrazoxane Possible Side Effects

Dexrazoxane has the potential to cause certain side effects in some animals. The most common possible side effects include diarrhea, loss of hair and general nausea. If the animal experiences itching, hives, swelling of the face, lips or tongue, skin rash or difficulty breathing, this may indicate an allergic reaction.

Other serious potential side effects include vomiting, lethargy, sores in the mouth, unusual bleeding or bruising or a fever. If your pet displays any serious adverse reactions or signs of an allergic reaction, contact the veterinarian immediately.

Author: Giano Panzarella