Hyaluronidase Facilitates Dispersion of Important Drugs in Pets

Hyaluronidase belongs to a family of enzymes that degrade hyaluronic acid. Since it increases the permeability of tissues by lowering the viscosity of hyaluronic acid, Hyaluronidase is most commonly used in tandem with other medications in order to facilitate the delivery and dispersion of the other drugs.

Veterinary Use of Hyaluronidase

Veterinarians prescribe Hyaluronidase primarily to help increase the absorption rate of other injected drugs. However, this enzyme is also used to treat hypodermoclysis, and in cases of subcutaneous urography in which the resorption of radiopaque agents needs to be improved.

Other, less-frequent uses for Hyaluronidase include the treatment of diabetic retinopathy and vitreous hemorrhage.

How Is Hyaluronidase Administered?

Hyaluronidase is only available in an injection formulation and depending on the reason for use, it may be injected subcutaneously or intravenously. Administration of this medication is usually performed by the veterinarian in a hospital setting or in the veterinary office. The drug is usually not recommended for at-home administration.

Hyaluronidase Drug Incompatibilities

Hyaluronidase may interact with certain other drugs such as furosemide, benzodiazepines, antihistamines, corticotropins, estrogens, salicylates, cortisone, local anesthetics and phenytoin. In order to prevent or reduce the risk of a possible drug interaction, the patient’s current drug regimen should be discussed with the veterinarian prior to administering Hyaluronidase.

Possible Side Effects of Hyaluronidase

Hyaluronidase is generally well-tolerated by most patients, although some mild side effects may be experienced, including injection site tenderness, redness and swelling. More serious side effects include angioedema and uticaria, but occurrences are rare.

Hyaluronidase Precautions

Since Hyaluronidase is a naturally-occurring enzyme in the body, precautions are of little concern. If the patient has experienced allergic reactions to this medication previously, then the drug should not be administered.

Author: Giano Panzarella