Piroxicam is a non-steroidal anti-inflammatory (NSAID) drug belonging to the oxicam class. It’s available for human use under a variety of trade names, including Feldene, Roxam, and Dolonex. In humans, it’s used as an analgesic, to relieve arthritis symptoms, and to ease postoperative pain.

Piroxicam In Veterinary Medicine

In veterinary medicine, Piroxicam is most often prescribed to treat certain types of cancers, such as colon, prostate, and bladder cancer. It may also be used to treat arthritis pain, though other products are generally preferred for those purposes.

The exact mechanism by which Piroxicam combats mammary adenocarcinoma, squamous cell carcinoma, TCC, and other cancers, isn’t completely understood, bit its effectiveness is well known.

In veterinary chemotherapy, Piroxicam can be used to reduce the necessary dosage of Methotrexate, a drug used to treat certain types of lymphoma. It can also be combined with opoid analgesics to reduce discomfort in oncology patients, while reducing the drowsiness commonly associated with those drugs.

Piroxicam Formats

Piroxicam is typically administered orally, but is occasionally formulated for injection. Diamondback Drugs compounds Piroxicam in standard oral 10mg Diamond Tabs, but as a specialist in pharmaceutical compounding, they’re able to produce custom compounded Piroxicam in a variety of formulations.

Piroxicam Interactions

Piroxicam can be extremely toxic if administered together with Methotrexate, and may decrease the efficacy of furosemide.

As a protein-bound drug, Piroxicam may alter the effectiveness of other protein-bound medications, such as phenytoin, valproic acidoral antacids, salicylates, sulfonamides, and sulfonylurea antidiabetic compounds.

If used with aspirin or other anticoagulants, Piroxicam may increase the risk of bleeding, and may raise chances of gastrointestinal ulceration when administered in combination with biphosphonates, aspirin, or corticosteroids. Renal toxicity may result if Piroxicam is given in concert with cisplatin or aminoglycoside antibiotics.

Piroxicam Potential Side Effects

Piroxicam should be used with caution in dogs with cardiac issues. It should not be given to dehydrated animals, and its use may require additional hydration. GI ulceration is a potential side effect, so animals taking Piroxicam should be monitored for symptoms such as vomiting, or loose, tarry stool. If these symptoms present, then a veterinarian should be contacted immediately.

Author: Giano Panzarella

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